Dominantly acting variants in ATP6V1C1 and ATP6V1B2 cause a multisystem phenotypic spectrum by altering lysosomal and/or autophagosome function

Fluorescent Labeling Can Significantly Perturb Measured Binding Affinity and Selectivity of Peptide-Protein Interactions

Computational Evaluation of Peptide-Protein Binding Affinities: Application of Potential of Mean Force Calculations to SH2 Domains

Isoamphipathic antibacterial molecules regulating activity and toxicity through positional isomerism

Mechanism of lipid bilayer perturbation by bactericidal membrane-active small molecules

Aggregation properties of a therapeutic peptide for rheumatoid arthritis: A spectroscopic and molecular dynamics study

Caenorhabditis elegans provides an efficient drug screening platform for GNAO1-related disorders and highlights the potential role of caffeine in controlling dyskinesia

Discriminating between competing models for the allosteric regulation of oncogenic phosphatase SHP2 by characterizing its active state

Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein-Protein Interactions

Compound heterozygosity for PTPN11 variants in a subject with Noonan syndrome provides insights into the mechanism of SHP2-related disorders

Formulation matters! A spectroscopic and molecular dynamics investigation on the peptide CIGB552 as itself and in its therapeutical formulation

Sound-driven dissipative self-assembly of aromatic biomolecules into functional nanoparticles

Aggregation propensity of therapeutic fibrin-homing pentapeptides: Insights from experiments and molecular dynamics simulations

Co-occurring WARS2 and CHRNA6 mutations in a child with a severe form of infantile parkinsonism

Pathogenic PTPN11 variants involving the poly-glutamine Gln²⁵⁵-Gln²⁵⁶-Gln²⁵⁷ stretch highlight the relevance of helix B in SHP2's functional regulation

Structural Determinants of Phosphopeptide Binding to the N-Terminal Src Homology 2 Domain of the SHP2 Phosphatase

Enhanced MAPK1 Function Causes a Neurodevelopmental Disorder within the RASopathy Clinical Spectrum

A Recurrent Gain-of-Function Mutation in CLCN6, Encoding the ClC-6 Cl⁻/H⁺-Exchanger, Causes Early-Onset Neurodegeneration

Gold Nanoparticle Aggregates Functionalized with Cyclic RGD Peptides for Targeting and Imaging of Colorectal Cancer Cells

Rational design of antiangiogenic helical oligopeptides targeting the vascular endothelial growth factor receptors

Orienting proteins by nanostructured surfaces: Evidence of a curvature-driven geometrical resonance

Selectively targeting bacteria by tuning the molecular design of membrane-active peptidomimetic amphiphiles

Clinical and functional characterization of two novel ZBTB20 mutations causing Primrose syndrome

Mutations in KCNK4 that Affect Gating Cause a Recognizable Neurodevelopmental Syndrome

The influence of ph on the scleroglucan and scleroglucan/borax systems

Enhanced EGFR targeting activity of plasmonic nanostructures with engineered GE11 peptide

Molecular dynamics simulations of the host defense peptide temporin L and Its Q3K Derivative: An atomic level view from aggregation in water to bilayer perturbation

Structural, Functional, and Clinical Characterization of a Novel PTPN11 Mutation Cluster Underlying Noonan Syndrome

Carnitine palmitoyl transferase-1A (CPT1A): A new tumor specific target in human breast cancer

Relative stability of the scleroglucan triple-helix and single strand: An insight from computational and experimental techniques

Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome

Theoretical and experimental study on a self-assembling polysaccharide forming nanochannels: Static and dynamic effects, induced by a soft confinement